Racemic and Optically Active 2,9-Dimethyl-5-(m-hydroxyphenyl)morphans and Pharmacological Comparison with the 9-Demethyl Homologues

Article abstract of DOI:10.1021/jm00370a019

2,9α-Dimethyl-5-(m-hydroxyphenyl)morphan (3a) has been synthesized from 5-(m-methoxyphenyl)-2-methyl-9-oxomorphan (4) and resolved into its enantiomers (+)-3a and (-)-3a.The assigned α-orientation of the 9-methyl group was derived from studies of induced