
Tetrahedron Letters p. 4637 - 4640 (1983)
Update date:2022-07-31
Topics:
Heathcock, Clayton H.
Montgomery, Stephen H.
(+/-)-Ristosamine (1) has been synthesized in seven straigthforward operations from ketone 5 and O-benzyllactaldehyde.The key step is a stereoselective aldol addition reaction in which diastereomeric aldols 7 and 8 are produced in a ratio of 78:22.A simpl
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