Synthesis and antibacterial activity of 1β-methyl-2-[5-(1,2- disubstituted ethyl)pyrrolidin-3-ylthio]carbapenem derivatives

Article abstract of DOI:10.1002/ardp.200500139

The synthesis of a new series of 1β-methylcarbapenems having a 5-(1,2-disubstituted ethyl) pyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of the sub