ORGANIC REACTIONS AT HIGH PRESSURE. A MILD METHOD FOR THE PLACEMENT OF PROTECTING GROUPS ON HINDERED AND SENSITIVE ALCOHOLS

Article abstract of DOI:10.1016/S0040-4039(00)94179-0

A series of hindered and/or labile alcohols has been derivatized with a variety of acyalting and silylating agents using pyridine in methylene chloride at 15 kbar (1.5 GPa) pressure to afford excellent yields of protected alcohols at 20 deg C, largely wit