Approaches to the Synthesis of Cytochalasans. Part 6. Sythesis of the C(14)-C(23) Subunit of Cytochalasins A, B, F and Desoxaphomin

Article abstract of DOI:10.1002/hlca.19840670132

The synthesis of methyl (4R,8R,)-10-bromo-8-methyl-4-(1,3,6-trioxaheptane)-2-decenoate(5) a synthon for the construction of the macrocyclic moieties of the cytochalasins A (1), B (2), F (3) and desoxaphomin (4) is described. (S)-Glutamic acid (6) was tran