Synthesis and Conformational Studies by X-ray Crystallography and Nuclear Magnetic Resonance of cyclo(L-Phe-L-Pro-D-Ala)2

Article abstract of DOI:10.1021/ja00325a023

cyclo(Phe-Pro-D-Ala)2, C34H42N6O6, was synthesized from the hydrochloride of Pro-D-Ala-OMe.NMR data indicate that the two-cis backbone is the major form in solution.Crystals were obtained from a solution of the peptide in a mixture of Me2SO and water and