Discovery and SAR study of novel dihydroquinoline containing glucocorticoid receptor ligands

DOI: 10.1016/j.bmcl.2005.12.043

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1549 - 1552 (2006)

Update date:2022-08-04

Topics:

Authors:

Takahashi, Hidenori

Bekkali, Younes

Capolino, Alison J.

Gilmore, Thomas

Goldrick, Susan E.

Nelson, Richard M.

Terenzio, Donna

Wang, Ji

Zuvela-Jelaska, Ljiljana

Proudfoot, John

Nabozny, Gerald

Thomson, David

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Article abstract of DOI:10.1016/j.bmcl.2005.12.043

We report the discovery of a novel class of glucocorticoid receptor (GR) ligands based on 1,2-dihydroquinoline molecular scaffold. The compounds exhibit good GR binding affinity and selectivity profile against other nuclear hormone receptors.

Full text of DOI:10.1016/j.bmcl.2005.12.043

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