Synthesis and phosphatase inhibitory activity of analogs of sulfircin

DOI: 10.1016/S0960-894X(97)00357-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2015 - 2020 (1997)

Update date:2022-08-03

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Authors:

Cebula, Regina E.

Blanchard, Jill L.

Boisclair, Michael D.

Pal, Kollol

Bockovich, Nicholas J.

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Article abstract of DOI:10.1016/S0960-894X(97)00357-0

Analogs of sulfircin (1) were synthesized and tested for inhibitory activity against a panel of phosphatases. We attempted to optimize the potency and selectivity of sulfircin for Cdc25A by modifying three structural areas of the molecule. An anionic grou

Full text of DOI:10.1016/S0960-894X(97)00357-0

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