4
Tetrahedron Letters
12. Zhou, Y.; Rao, C.; Mai, S.; Song, Q. J. Org. Chem. 2016, 81, 2027-2034.
In conclusion, a new copper-catalyzed one-pot procedure has
13. Ke, J.; Tang, Y.; Yi, H.; Li, Y.; Cheng, Y.; Liu, C.; Lei, A. Angew.
Chem., Int. Ed. 2015, 54, 6604-6607.
been developed for the synthesis of β-ketophosphine oxides from
various ketones and H-phosphine oxides under air at room
temperature. The present protocol provides an efficient and
attractive route to various β-ketophosphine oxides in moderate to
good yields with good functional group tolerance. Preliminary
mechanistic studies revealed that the reaction might involve a
radical process and the carbonyl oxygen atom was derived from
molecular oxygen. Further studies to clearly understand the
reaction mechanism and the potential synthetic applications are
ongoing in our laboratory.
14. (a) Li, M. S.; Zhang, Q.; Hu, D. Y.; Zhong, W. W.; Cheng, M.; Ji, J. X.;
Wei, W. Tetrahedron Lett. 2016, 57, 2642-2646; (b) Fu, Q.; Yi, D.;
Zhang, Z.; Liang, W.; Chen, S.; Yang, L.; Zhang, Q.; Ji, J.; Wei W. Org.
Chem. Front, 2017, DOI: 10.1039/C7QO00202E; (c) Yi, D.; Fu, Q.;
Chen, S-Y.; Gao, M.; Yang, L.; Zhang, Z-J.; Liang, W.; Zhang, Q.; Ji, J-
X.; Wei, W. Tetrahedron Lett. 2017, 10.1016/j.tetlet.2017.04.042; (d)
Liu, C.; Wei, W.; Yang, D.; Zheng, Y.; Bi, Y.; Chen, M.; Wang, H.
Tetrahedron, 2015, 71, 6901-6906; (e) Liu, C. L.; Zhu, M. H.; Wei, W.;
Yang, D. S.; Cui, H.; Liu, X. X.; Wang, H. Org. Chem. Front. 2015, 2,
1356-1360.
15. (a) Liu, Y. X.; Xu, C. F.; Liu, L. Z. Synthesis 2003, 1335-1338; (b) Wei,
W.; Liu, C.; Yang, D.; Wen, J.; You, J.; Suo, Y.; Wang, H. Chem.
Commun., 2013, 49, 10239-10241; (c) Wei, W.; Wen, J.; Yang, D.; Wu,
M.;You, J.; Wang, H. Org. Biomol. Chem., 2014, 12, 7678-7681; (d)
Wei W.; Wen, J.; Yang, D.; Guo, M.; Tian, L.; You, J.; Wang, H. RSC
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Acknowledgements
We gratefully acknowledge financial support from the
Chinese National Natural Science Foundation (No.
21402184, 21572217, and 21302109) and Institute of Drug
16. Nair, V.; Biju, A. T.; Mathew, S. C. Synthesis 2007, 697-704.
Innovation,
Chinese
Academy
of
Sciences
(CASIMM0420152013 and CASIMM0420151009); Strategic
Biological Resources Service Network Program of Chinese
Academy of Sciences (ZSTH-001).
Supplementary data
Supplementary data associated with this article can be found, in
the online version, at http://dx.doi.org/10.1016/j.tetlet.****
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