Design and synthesis of a series of novel pyrazolopyridines as HIF 1-α prolyl hydroxylase inhibitors

Article abstract of DOI:10.1016/j.bmcl.2006.08.017

Recently resolved X-ray crystal structure of HIF-1α prolyl hydroxylase was used to design and develop a novel series of pyrazolopyridines as potent HIF-1α prolyl hydroxylase inhibitors. The activity of these compounds was determined in a human EGLN-1 assa