Stabilization of cysteine-linked antibody drug conjugates with N-aryl maleimides

DOI: 10.1016/j.jconrel.2015.09.032

Source and publish data:

Journal of Controlled Release p. 660 - 670 (2015)

Update date:2022-08-05

Topics:

Authors:

Christie, R. James

Fleming, Ryan

Bezabeh, Binyam

Woods, Rob

Mao, Shenlan

Harper, Jay

Joseph, Augustine

Wang, Qianli

Xu, Ze-Qi

Wu, Herren

Gao, Changshou

Dimasi, Nazzareno

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Article abstract of DOI:10.1016/j.jconrel.2015.09.032

Maleimides are often used to covalently attach drugs to cysteine thiols for production of antibody-drug conjugates (ADCs). However, ADCs formed with traditional N-alkyl maleimides have variable stability in the bloodstream leading to loss of drug. Here, w

Full text of DOI:10.1016/j.jconrel.2015.09.032

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