Stabilization of cysteine-linked antibody drug conjugates with N-aryl maleimides

Article abstract of DOI:10.1016/j.jconrel.2015.09.032

Maleimides are often used to covalently attach drugs to cysteine thiols for production of antibody-drug conjugates (ADCs). However, ADCs formed with traditional N-alkyl maleimides have variable stability in the bloodstream leading to loss of drug. Here, w