ENZYMIC CONTROL OF STEREOCHEMISTRY AMONG THE THALICTRUM BISBENZYLISOQUINOLINE ALKALOIDS

Article abstract of DOI:10.1016/S0040-4020(01)88437-4

The new bisbenzylisoquinolines (+)-thaligrisine and (+)-thaliphylline 6 have been isolated from Thalictrum minus var. microphyllum.Four rules are described which correlate the structures os Thalictrum bisbenzylisoquinolines with their stereochemistry at C-1 and C-1'.As a result, (+)-thalrugosamine is shown to be identical with (+)-homoaromoline 14. (+)-Thalisamine and (+)-N'-norhernandezine are also identical and are represented by expression 18.The sole exception to the rules is (-)-isothalidezine 15.