Design, synthesis, and structure-activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors

DOI: 10.1016/j.bmcl.2012.04.047

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3643 - 3647 (2012)

Update date:2022-08-02

Topics:

Authors:

Kamata, Makoto

Yamashita, Tohru

Kina, Asato

Funata, Masaaki

Mizukami, Atsushi

Sasaki, Masako

Tani, Akiyoshi

Funami, Miyuki

Amano, Nobuyuki

Fukatsu, Kohji

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/j.bmcl.2012.04.047

Spiro-lactone (S)-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor and was found to be metabolically liable in human hepatic microsomes. To remove one of the risk factors in human study by improving the metabolic stability, we focused on modifying the

Full text of DOI:10.1016/j.bmcl.2012.04.047

Products guided by the article

Product name:1-tert-butyl 3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]piperidine-1,3-dicarboxylate

Cas No:923009-79-4

R&D Labs maybe for 923009-79-4

Wuhan HengHeDa Pharm Co., Ltd

Contact:86-27-84888681

Address:Wuhan economic & technology development zone
Shandong Yuanli Science and Technology Co., Ltd.

Contact:86-0536-6777557

Address:Zhuliu Industiral Park,Changle County
Zibo Linzi Darong Fine Chemical Co., Ltd(expird)

Contact:86-532-67773200; 15689126900

Address:Qidu town,Linzi district,Zibo city,Shandong province,China
Cartoon Ingredients Co., Ltd

website:http://www.cartoonchem.com/

Contact:+86-25-58074918

Address:Room 2109, RuiHua Business Center,315 South ZhongShan Road, Nanjing 210001, China
Fusilin chemical science & technology co., ltd.

Contact:532-80698166/86057573, +86-400-669-7885

Address:School of Material Science & Engineering, Shandong Uinversity of Science & Technology, Huangdao Zone, Qindao, Shandong

Relevant to this article

Synthesis of Aliphatic Carboxamides Mediated by Nickel NN₂-Pincer Complexes and Adaptation to Carbon-Isotope Labeling

Doi:10.1002/chem.201804077
(2018)
Synthesis of 6-(perfluoroalkyl)salicylates by [3+3] cyclization of 1,3-bis(silyl enol ethers) with 3-ethoxy-1-(perfluoroalkyl)prop-2-en-1-ones

Doi:10.1016/j.tet.2006.10.062
(2007)
Direct photochemical trifluoromethylation of histidine-containing peptides

Doi:10.1016/S0040-4039(00)97937-1
(1990)
Doi:10.1021/ja01562a037
(1957)
Lewis acid mediated asymmetric [2,3]-sigmatropic rearrangement of allylic amines. Scope and mechanistic investigation

Doi:10.1021/jo062178v
(2007)
Total stereochemical control in the addition of thiols to p-toluenesulfonylacetylene. Synthesis of Z-and E-2-sulfanylvinylsulfonyl derivatives

Doi:10.1021/jo0402576
(2005)

Article Doi