Ureidopyridazine derivatives as acyl-CoA:cholesterol acyltransferase inhibitors

Article abstract of DOI:10.3797/scipharm.2006.74.85

A series of N-(2,4-difluorophenyl)-N′-heptyl-N′-{4- [(substituted)-pyridazin-3-yl)thio]pentyl}urea derivatives having a phenyl ring at positions 5 and/or at position 6 of the heterocycle, as well as the corresponding sulfones, were synthesized. Their inhi