α-Amino Acids as Chiral Educts for Asymmetric Products. Chirospecific Syntheses of Methyl L-Sibirosaminide and Its C-3 Epimer from L-Allothreonine

Article abstract of DOI:10.1021/jo00203a008

Efficient syntheses of methyl L-sibirosaminide and its C-3 epimer are described using L-allothreonine as the chiral educt.Amino acylations of organometallics with the lithium salt of N-(phenylsulfonyl)-L-allothreonine constitute the key carbon-carbon bond