Tetrahedron Letters p. 4483 - 4486 (1984)
Update date:2022-09-26
Topics:
Teetz, V.
Gaul, H.
Spiro<4.n>-2-aza-alkan-carboxylic acids represent bulky proline analogues with increased lipophilicity.They are readily available from cyclic nitriles via alkylation with bromoacetaldehyde acetals, reduction to the corresponding amine, cyclisation to the
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