Regio- and stereoselective heck arylations of N-carbomethoxy-L-3- dehydroproline methyl ester with arenediazonium salts. Total synthesis of neuroexcitatory aryl kainoids

Article abstract of DOI:10.1021/ol070980t

The Heck arylation of N-carbomethoxy-L-3-dehydroproline methyl ester with arenediazonium tetrafluoroborates produced chiral 4-aryldehydroproline derivatives in moderate to good yields in a highly regio- and stereocontrolled fashion. A rationale for the un