Tetrahedron Letters p. 6537 - 6540 (1988)
Update date:2022-08-05
Topics:
Gerdes, John M.
Mathis, Chester A.
Shulgin, Alexander T.
Synthesis of the titled 2,5-dimethoxy-4-fluoroalkylamphetamine is reported.The highly functionalized aromatic nucleus of the key fluorination precursor was utimately derived from a low temperature aromatic halogen-lithium exchange reaction followed by alkylation of the resultant anion with ethylene oxide.
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