A practical conversion of an azetidinone to penem: Synthesis of Sch 34343

DOI: 10.1016/S0040-4020(01)90781-1

Source and publish data:

Tetrahedron p. 1175 - 1182 (1992)

Update date:2022-08-04

Topics:

Authors:

Gala Gala

Chiu Chiu

Ganguly Ganguly

Girijavallabhan

Jaret Jaret

Jenkins Jenkins

McCombie

Nyce Nyce

Rosenhouse

Steinman

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Article abstract of DOI:10.1016/S0040-4020(01)90781-1

A synthesis of penems from azetidinone 1 is described in detail. This synthesis is used to prepare multikilo batches of (5R,6S)-2-[[-(carbamoyloxy)ethyl]thio]-6-[(R)-1-hydroxyethyl]penem-3-carboxylic acid (10), (Sch 34343). It is practical as all chemical

Full text of DOI:10.1016/S0040-4020(01)90781-1

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Product name:(5R,6S)-3-{[2-(carbamoyloxy)ethyl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

Cas No:95415-91-1

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