Bioorganic and Medicinal Chemistry Letters p. 2998 - 3002 (2007)
Update date:2022-08-04
Topics:
Feng, Zixia
Mohapatra, Suchismita
Klimko, Peter G.
Hellberg, Mark R.
May, Jesse A.
Kelly, Curtis
Williams, Gary
McLaughlin, Marsha A.
Sharif, Najam A.
A series of 8-substituted benzodifuran analogs was prepared and evaluated for 5-HT2A receptor binding and activation. Several compounds containing ether and ester functionality were found to be potent agonists. Topical ocular administration of 5, 18, and 25 effectively reduced intra-ocular pressure in the hypertensive cynomolgus monkey eye in the range of 25-37%.
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Doi:10.1021/ja074488g
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