Synthesis of the Spiroacetal Unit Related to the Avermectins and Milbemycins

DOI: 10.1039/c39840001381

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1381 - 1382 (1984)

Update date:2022-07-31

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Authors:

Godoy, Jose

Ley, Steven V.

Lygo, Barry

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Article abstract of DOI:10.1039/c39840001381

A route to enantiomerically pure 1,7-dioxaspiro<5.5>undecanes as important building blocks for milbemycin/avermectin synthesis is described, involving the Wittig reaction of a substituted cyclic ether with aldehydes, followed by spiroacetalisation.

Full text of DOI:10.1039/c39840001381

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