Chemistry Letters p. 1041 - 1044 (1985)
Update date:2022-08-04
Topics:
Matsueda, Rei
Yabe, Yuichiro
Kogen, Hiroshi
Higashida, Susumu
Koike, Hiroyuki
et al.
The phenylalanine residue in the C-terminal sequence of angiotensin II was found to be important for the design of renin inhibitors. 1-Naphthylalanine(Nal(1))-containing tripeptide analogues such as benzyloxycarbonyl-Na1(1)-His-Leucinal (ES-188) and benzyloxycarbonyl-Nal(1)-His-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid (Statine)5 2(S)-methylbuthylamide (ES-254) showed high potency and specificity to human renin.
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Doi:10.1021/jo01059a018
(1962)Doi:10.1007/BF00505911
(1985)Doi:10.1016/S0040-4039(00)61945-7
(1985)Doi:10.1021/acs.jmedchem.7b01584
(2018)Doi:10.1021/ja00299a072
(1985)Doi:10.1080/10426500008076551
(2000)
