Journal of Medicinal Chemistry p. 1031 - 1036 (1985)
Update date:2022-08-04
Topics:
Cushman, Mark
Mohan, Prem
The indenoisoquinoline analogue 4 of fagaronine chloride (2) has been prepared, as well as its positional isomer 20 and the corresponding mesylated derivatives 16 and 19.Compounds 4, 16, and 20 were tested against P388 lymphocytic leukemia and found to possess significant activity.A tricyclic analogue 24 was also synthesized and was devoid of cytotoxicity in the KB cancer cell culture system.The change in the substitution pattern of the A-ring on going from 4 to 20 was tolerated without producing a significant decrease in antitumor activity.
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