Regioselective dehydration in cyclic system with triphenylphosphine-azodicarboxylate

Article abstract of DOI:10.1016/S0040-4039(00)92046-X

The regioselective dehydration of cyclohexanol derivatives was achieved by using the Mitsunobu reagent system. The reaction undergoes under mild and neutral conditions. The observed regioselectivity was explained by considering the importance of the orientation of the leaving group at the elimination stage.