Nucleophilic cleavage of acetals using organometallic reagents

Article abstract of DOI:10.1016/0022-328X(85)87359-9

A highly chemo- and stereo-selective cleavage of acetals derived from (-)(2R,4R)-2,4-pentanediol with organoaluminum and organotitanium reagents has been demonstrated. The reactions proceed under mild conditions with excellent yields and high chemoselectivities to give, after removal of the auxiliary, chiral alcohols of high enantiomeric purities.