A simple synthetic method for tetraaza[3.3.3.3]meta- and paracyclopanes by alkylation of N-substituted trifluoroacetamide

Article abstract of DOI:10.1055/s-1993-26038

A simple and practical synthesis of the title compounds 1b and 2b is described. Alkylation of N-substituted trifluoroacetamides (5a and b) with appropriate dibromides (6 and 9) in the presence of sodium hydride in N,N-dimethylformamide at 100°C, or powder