Chemical modification of tazobactam. Synthesis of 2β-[(4-substituted)-1,2,3-triazol-1-yl]methyl penicillanic acid sulfone derivatives

Article abstract of DOI:10.7164/antibiotics.48.1320

A series of 2β-[(4-substituted)-1,2,3-triazol-1-yl]methyl penicillanic acid sulfones was synthesized as β-lactamase inhibitors. Many of these compounds showed good in vitro inhibitory activity against penicillinase, cefotaximase and plasmid-mediated class