FIRST PREPARATION OF (+)-SPATHULENOL. REGIO- AND STEREOSELECTIVE OXIDATION OF (+)-AROMADENDRENE WITH OZONE.

Article abstract of DOI:10.1016/S0040-4039(00)94792-0

(+)-Spathulenol was prepared for the first time in three reaction steps from (+)-aromadendrene by two subsequent ozonizations the second of which was regio- and stereoselective, followed by a wittig reaction.The overall recycle yield was 13percent.