Ion Selective Liquid Membrane Electrode for the Assay of Lithium in Blood Serum

Article abstract of DOI:10.1021/ac00292a032

The lipophilic neutral carrier N,N-dicyclohexyl-N',N'-diisobutyl-cis-cyclohexane-1,2-dicarboxamide has been tested in different liquid membranes in order to evaluate its potential use in the potentiometric assay of Li⁺ in blood serum for monitoring the lithium therapy of manic-depressive psychosis.One of the membranes showed sufficient selectivity against the interfering cations for the Li⁺ assay in blood using a fixed potential, reproducibility, and the response time in aqueous solutions and serum make a practical use of Li⁺-selective electrodes based on this membrane possible.