Pharmacomodulation d'adrenolytiques α en serie benzopyrannique

Article abstract of DOI:10.1016/0223-5234(87)90294-7

Pharmacomodulation of α-adrenergic blocking agents by a series of benzopyrans.The N-methylpiperidine fragment was associated with four oxygenated heterocycles of the benzopyran ring system.Two different synthesis pathways were used in each case.Twenty intermediate derivatives and four aminomethylated derivatives whose structures were established by spectroscopic data are described.The pharmacological investigation demonstrates the interest of these compounds on the α-adrenergic receptors in light of their activities and selectivities. α₁-adrenergic blocking agents / α₂-adrenergic blocking agents / piperidinomethyl chromone, chromene and chromane