POLYMER SUPPORTED DNA SYNTHESIS USING HYDROXYBENZOTRIAZOLE ACTIVATED PHOSPHOTRIESTER INTERMEDIATES

DOI: 10.1016/S0040-4039(00)88244-1

Source and publish data:

Tetrahedron Letters p. 3989 - 3992 (1983)

Update date:2022-08-03

Topics:

Authors:

Marugg, J.E.

McLaughlin, L.W.

Piel, N.

Tromp, M.

Marel, G.A. van der

Boom, J.H. van

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Article abstract of DOI:10.1016/S0040-4039(00)88244-1

In the present method appropriate N-protected-5'-O-(4,4'-dimethoxytrityl)-2'-deoxynucleosides are phosphorylated with the reagent 2-chlorophenyl-O,O-bis(1-benzotriazolyl)-phosphate and the 3'-phosphorylated intermediates thus obtained are used directly to

Full text of DOI:10.1016/S0040-4039(00)88244-1

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