Angiotensin converting enzyme inhibitors. 10. Aryl sulfonamide substituted N-[1-carboxy-3-phenylpropyl]-L-alanyl-L-proline derivatives as novel antihypertensives

DOI: 10.1021/jm00168a013

Source and publish data:

Journal of Medicinal Chemistry p. 1606 - 1615 (1990)

Update date:2022-08-05

Topics:

Authors:

Mencel Mencel

Regan Regan

Barton Barton

Menard Menard

Bruno Bruno

Calvo Calvo

Kornberg

Schwab Schwab

neiss neiss

Suh Suh

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Article abstract of DOI:10.1021/jm00168a013

Compounds 1a-g consisting of enalaprilat covalently bonded to aryl sulfonamides, including several known thiazide diuretics, were synthesized and tested for ACE inhibitory and diuretic and overall antihypertensive effects. All compounds were potent ACE in

Full text of DOI:10.1021/jm00168a013

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