An Efficient Catalytic Friedel-Crafts Acylation Reaction of Equimolar Amounts of Aromatic Compounds and Free Carboxylic Acids or Their Trimethylsilylesters via Mixes Anhydrides

Article abstract of DOI:10.1246/cl.1992.1751

In the presence of an active catalyst generated from SiCl4 and AgClO4, the Friedel-Crafts acylation reaction between equimolar amount of aromatic compounds and mixed anhydrides, formed in situ from free carboxylic acids (or their trimethylsilylesters) and p-trifluoromethylbenzoic anhydride, smoothly proceeds at room temperatureto afford the corresponding aromatic ketones in high yields.