IRON CATALYZED CROSS-COUPLING REACTIONS OF ACYL CHLORIDES WITH GRIGNARD REAGENTS. A MILD, GENERAL, AND CONVENIENT SYNTHESIS OF ALIPHATIC AND AROMATIC KETONES.

DOI: 10.1016/S0040-4039(01)81525-2

Source and publish data:

Tetrahedron Letters p. 4805 - 4808 (1984)

Update date:2022-08-11

Topics:

Authors:

Fiandanese, V.

Marchese, G.

Martina, V.

Ronzini, L.

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Article abstract of DOI:10.1016/S0040-4039(01)81525-2

Acyl chlorides couple with Grignard reagents at room temperature in the presence of catalytic amounts of tris(acetylacetonate)iron(III), Fe(acac)3.The reaction is general with respect to both reactants and provides a very mild and convenient method for the synthesis of aliphatic and aromatic ketones.

Full text of DOI:10.1016/S0040-4039(01)81525-2

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