Organomanganese (II) reagents XXIII: Manganese-catalyzed acylation of organomagnesium compounds by car·ylic acid chlorides

Article abstract of DOI:10.1016/S0040-4039(00)60104-1

In the presence of a catalytic amount of manganese chloride (3% MnCl₄Li₂), organomagnesium reagents react with car·ylic chlorides, in THF between 0 and 10°C, to give the corresponding ketones in high yields. The scope of the reaction is very large; alkyl, alkenyl and aryl magnesium reagents have been used successfully. The selectivity of the reaction allows to prepare various fonctionalized ketones from car·ylic acid chlorides bearing a functional group (Cl, Br, ester nitrile and even a ketone).