Synthesis of N1-unsubstituted (β-lactams : Introducing n1-(1'-thiophenyl)benzyl as an N-protecting group

Article abstract of DOI:10.1016/S0040-4039(97)00879-4

A diastereoselective synthesis of (±) cis-β-lactams (5 and 6) via cycloaddition reaction of N¹-(α-thiophenyl)benzyl imines (3) with acid chlorides (4) in the presence of triethyl amine is described. Deprotection of N¹-(α-thiophenyl)benzyl group was achieved in good yields by oxidation using potassium persulfate.