Bioorganic and Medicinal Chemistry Letters p. 2491 - 2494 (1996)
Update date:2022-08-12
Topics:
Brinkman, John A.
Damon, Robert E.
Fell, Jay B.
Perez, Lawerence B.
Scallen, Terence J.
Vedananda
Squalene synthase catalyzes the committed step of cholesterol biosynthesis. We report here the synthesis and in vivo activity of a series of squalene synthase inhibitors that contain isosteric replacements for the farnesyl chain of the known inhibitor ben
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