Squalene synthase inhibitors: Isosteric replacements of the farnesyl chain of benzyl farnesyl amine

DOI: 10.1016/0960-894X(96)00470-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2491 - 2494 (1996)

Update date:2022-08-12

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Authors:

Brinkman, John A.

Damon, Robert E.

Fell, Jay B.

Perez, Lawerence B.

Scallen, Terence J.

Vedananda

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Article abstract of DOI:10.1016/0960-894X(96)00470-2

Squalene synthase catalyzes the committed step of cholesterol biosynthesis. We report here the synthesis and in vivo activity of a series of squalene synthase inhibitors that contain isosteric replacements for the farnesyl chain of the known inhibitor ben

Full text of DOI:10.1016/0960-894X(96)00470-2

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