Synthesis of 131I derivatives of indolealkylamines for brain mapping

Article abstract of DOI:10.1002/(SICI)1099-1344(199708)39:8<677::AID-JLCR9>3.0.CO;2-G

The synthesis and spectral properties of new radioiodinated indolealkylamines like 2-[¹³¹ I]-iodo-N,N-dimethyltryptamine, 2-[¹³¹ I]-iodo-N-methyltryptamine, 2-[¹³¹ I]-iodo-5-methoxy-N,N-dimethyltryptamine, 2-[¹³¹ I]-iodo-5-hydroxy-N,N-dimethyltryptamine (2-[¹³¹ I]-iodo-bufotenine), and 2-[¹³¹I]-iodo-tryptamine and the known 2-[¹³¹I]-iodo-N-acetyl-5-methoxy-tryptamine (2-[¹³¹I]-iodo-melatonine) are described herein. These were synthesized by a high-yield novel method, and their spectral properties are fully described. These compounds are of biological importance and can be used for brain mapping with SPECT technology.