Electron transfer in di(deoxy)nucleoside phosphates in aqueous solution: Rapid migration of oxidative damage (via adenine) to guanine

Article abstract of DOI:10.1021/ja00059a044

In aqueous solution, the one-electron loss centers created statistically by the oxidant SO₄^.- or by photoionization in di(2′-deoxy)nucleoside phosphates (DNPs) containing the base guanine (G) become localized at G, as concluded from pulse radiolysis and 193-nm laser photolysis experiments. From the latter it is evident that, in the case of adenylyl(3′→5′)guanosine (ApG), the charge-transfer process is complete in ≤50 ns. With DNPs containing a pyrimidine and the purine base adenine, the oxidative damage is collected by the adenine moiety (k ≥ 2 × 10⁵ s^-1).