Chemical and Pharmaceutical Bulletin p. 1786 - 1789 (2000)
Update date:2022-07-30
Topics:
Lim, Soon Sung
Jung, Sang Hoon
Ji, Jun
Shin, Kuk Hyun
Keum, Sam Rok
Inhibitory effects of synthetic 2'-hydroxychalcone derivatives on rat lens aldose reductase (RLAR) and on platelet aggregation were investigated for the prevention or the treatment of chronic diabetic complications. 5'-chloro-4,2'-dihydroxychalcone (8) and 5'-chloro-3,2'-dihydroxychalcone (27) exhibited a potent inhibitory effect on rat platelet aggregation induced by ADP (IC50=0.10 and 0.06 mg/ml, respectively) and collagen (IC50=44 and 16 μg/ml, respectively) but showed relatively weak inhibitory activities on RLAR.
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