Inhibitory effects of 2'-hydroxychalcones on rat lens aldose reductase and rat platelet aggregation

DOI: 10.1248/cpb.48.1786

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Chemical and Pharmaceutical Bulletin p. 1786 - 1789 (2000)

Update date:2022-07-30

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Authors:

Lim, Soon Sung

Jung, Sang Hoon

Ji, Jun Ji, Jun

Shin, Kuk Hyun

Keum, Sam Rok

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Article abstract of DOI:10.1248/cpb.48.1786

Inhibitory effects of synthetic 2'-hydroxychalcone derivatives on rat lens aldose reductase (RLAR) and on platelet aggregation were investigated for the prevention or the treatment of chronic diabetic complications. 5'-chloro-4,2'-dihydroxychalcone (8) and 5'-chloro-3,2'-dihydroxychalcone (27) exhibited a potent inhibitory effect on rat platelet aggregation induced by ADP (IC₅₀=0.10 and 0.06 mg/ml, respectively) and collagen (IC₅₀=44 and 16 μg/ml, respectively) but showed relatively weak inhibitory activities on RLAR.

Full text of DOI:10.1248/cpb.48.1786

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