Syntheses of 7-chloro-4-substituted aminoquinolines and their in vitro ability to produce methemoglobin in canine hemolysate

Article abstract of DOI:10.1016/S0960-894X(97)10074-9

Synthesis of aminoquinoline derivatives (2-15) and their in vitro effects on methemoglobin formation and methemoglobin reductase activity are delineated. Some of the screened compounds have shown considerable methemoglobin toxicity.