Dehalogenation of α-Halo Carbonyl Compounds by a New Efficient Reagent, Triphenylphosphonium Iodide

Article abstract of DOI:10.1246/cl.1992.293

Triphenylphosphonium iodide, Ph3PHI, was found to be an efficient reagent for the dehalogenation of α-halo carbonyl compounds. α-Halo esters, which were difficult to be reduced with Me3SiCl/NaI reagent, was smoothly debromiated by Ph3PHI.Treatment of α-halocarbonyl compounds with Ph3PDI produced the corresponding α-deuterated compounds.