Microbial Oxidation with Bacillus stearothermophilus: High Enantioselective Resolution of 1-Heteroaryl and 1-Aryl Alcohols

Article abstract of DOI:10.1016/S0957-4166(00)80367-5

Key Words: Microbial oxidation, Enantioselective resolution, 1-Heteroarylethanol, 1-Arylethanol, 1-(2-Thienyl)cyclopropanemethanol, Bacillus stearothermophilus The enantioselective resolution of the racemic 1-heteroaryl- and 1-arylethanols 1a-h via microbial oxidation with Bacillus stearothermophilus to give the R-enantiomers with high enantiomeric excesses is described.The kinetic resolution of 1-(2-thienyl)ethanol 1b by oxidation with Acinetobacter calcoaceticus anitrat to S-enantiomer (ee 100percent) is also reported.