Polymer-bound p-alkoxybenzyl trichloracetimidates: Reagents for the protection of alcohols as benzyl ethers on solid-phase

Article abstract of DOI:10.1016/S0040-4039(97)10684-0

Wang and Tentagel resins ware converted into their trichloroacetimidate dervatives and used as polymer-bound benzylating reagents for a variety of alcohols. Loading and cleavage proceed in good to excellent yields in the presence of BF₃.OEt₂ and 1% TFA respectively. The resins have excellent shelf life.