Journal of the Chemical Society. Perkin transactions I p. 1355 - 1362 (1985)
Update date:2022-08-29
Topics:
Gani, David
Young, Douglas W.
A mammalian enzyme system has been used to study the stereochemistry of the catabolism of the pyrimidine uracil (1) to the amino acid β-alanine (4).Use of <5-(2)H>- and <6-(2)H>- uracils and of (2)H2O in the incubations yielded sterospecifically deuteriated samples of β-alanine.Assays, involving total synthesis of samples of β-alanine unambigously labelled with deuterium in each of the four C-H bonds have shown that, in the first step in the catabolic process, uracil is reduced by dihydrouracil dehydrogenase with overall anti addition of hydrogen, at the si face at C-6 and the si face at C-5.
View MoreWEIFANG DERUN CHEMICAL CO.,LTD
Contact:86-536-8956886
Address:weifang
ZHUHAI HAIRUIDE BIOSCIENCE AND TECHNOLOGY CO.,LTD
website:http://www.zhhairuide.com
Contact:+8613326687259/+86-756-7789199
Address:No.10 Yonghui Road
Contact:+86-021-50792271
Address:Building 24A, 300 Chuantu Road, Chuansha, Pudong new area, Shanghai, China, 201202
Beyond Pharmaceutical Co., Ltd
Contact:+86-571-8195-3185
Address:No. 13-1, Liansheng Road, Yuhang District
Yuan Shi(SuQian)Biotechnology Co.,Ltd
website:http://www.yuanshibio.com
Contact:+86-527-84226672
Address:jiangsu suqian
Doi:10.1016/j.jorganchem.2007.07.003
(2007)Doi:10.1002/jccs.199900078
(1999)Doi:10.3390/molecules17043957
(2012)Doi:10.1002/jhet.786
(2012)Doi:10.1016/S0022-328X(00)96185-0
(1980)Doi:10.1039/j39670000128
(1967)
