Stereoselective synthesis of Z and E 3-F-alkyl 2-propenoates and derivatives

Article abstract of DOI:10.1016/0022-1139(95)03297-Q

The stereoselective preparation of 3-F-alkyl 2-propenoates and their derivatives is described.E-isomers are easily obtained by an in situ reduction-olefination from esters of F-acids and phosphonates or by a convenient dehydration of 3-F-alkyl 3-hydroxyesters.Z-isomers are known to be prepared by the hydrogenation of alkynes. - Keywords: Unsaturated ester; Unsaturated nitrile; F-Alkyl Chain; Dehydration; F-Enoyl sultam