Tetrahedron p. 305 - 322 (1994)
Update date:2022-08-16
Topics:
Larock, Richard C.
Yum, Eul K.
Yang, Hoseok
The palladium-catalyzed, intermolecular arylation of functionally-substituted cycloalkenes by aryl iodides affords a new synthetic route to a variety of arylated cyclic derivatives.The arylation of 2-cyclopenten-1-ol and 2-cyclo-hexen-1-ol provides modest yields of the corresponding 3-arylcycloalkanones, while 2-methyl-2-cyclopenten-1-ol affords a mixture of singly and doubly arylated cyclopentanone produts. 1-Acetoxycyclopentene undergoes arylation to produce the corresponding allylic aryl substitution product opening up a new route for the α-arylation of cycloalkanones.Cyclic allylic ethers undergo arylation at both ends of the C-C double bond to generate mixtures of singly arylated vinylic ethers. 1-Cyanocylopentene reacts with aryl iodides under palladium catalysis to produce 1-cyano-5-arylcyclopentenes in high yield. 2-Methyl-2-cycloalken-1-ones afford modest yields of doubly arylated 2-cycloalken-1-ones in a single step.
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