Conversion of Alkyl Halides into Alcohols Using a Near Stoichiometric Amount of Molecular Oxygen: An Efficient Route to 18O- And 17O-Labeled Alcohols

Article abstract of DOI:10.1055/s-1997-5779

In the presence of near stoichiometric amount of molecular oxygen, various alkyl halides were converted to the corresponding alcohols in high yields through aerobic radical reaction promoted by a Bu₂(t-Bu)SnCl/NaBH₃CN catalytic system. Isotope-labeled alcohols were prepared with ¹⁸O₂ and ¹⁷O₂ without loss of the isotopic purities of the starting oxygen gases.