DITERPENES FROM THE LATEX OF EUPHORBIA BROTERI

Article abstract of DOI:10.1016/0031-9422(88)80615-0

Six polycyclic diterpenes have been isolated from the latex of Euphorbia broteri Daveau.Two had a tigliane skeleton: 12-O-(2Z,4E-octadienoyl)-4-deoxyphorbol-13,20-diacetate and 12-O-(2Z,4E-octadienoyl)-phorbol-13,20-diacetate and four an ingenane skeleton: 20-acetyl-ingenol-3-decadienoate, 3-O-tetradecanoyl-ingenol, 20-O-tetradecanoyl-ingenol and 5-O-tetradecanoyl-ingenol.The second and last two compounds are described as natural compounds for the first time.Their structures were established by spectroscopic methods, by chemical correlations and by H/H and C/H correlations in their ¹H NMR and ¹³C NMR spectra.Key Word Index - Euphorbia broteri; Euphorbiaceae; latex; proinflammatory fractions; ingenol and phorbol mono-,di- and triesters; tetracyclic diterpenes.