Factor F430-Like Catalysis of Ni(tmptaa) (tmptaa = Dianion of 6,8,15,17-Tetramethyl-5,14-dihydrodibenzotetraazacyclotetradecine) for Reductive Dehalogenation of Alkyl Halides

Article abstract of DOI:10.1246/bcsj.67.705

Ni(tmptaa) efficiently catalyzes the reductive dehalogenation of alkyl halide, yielding alkane with either NaBH4 or NaBH(OMe)3 under mild conditions.This system is considered to be a model of factor F₄₃₀, the active center of the methyl coenzyme M reductase.Deuterium incorporation into the alkane suggests that the reaction involves not only an electron transfer, but also the nucleophilic substitution of a halide.The ESR spectrum of Ni(tmptaa)/NaBH4 shows the formation of the Ni^I species, which is probably a catalytic-active species.